Photo by Adam Wilson on Unsplash
Have you already read in our first part where a fatty liver comes from and where it leads? If not, you can find it at the following link. The second part was about what you can do against the possibility of fatty liver disease.
What should you know?
This topic is of interest to at least 35% of the population, because that is how many people have already developed a fatty liver. We have therefore decided to deal with the topic extensively in several parts.
Part 3
In this part, we want to convey to you what results therapy with PPC has in alcoholic fatty liver disease.
The alcohol and the destruction of erythrocytes (red blood cells)
An erythrocyte damaged by alcohol looks more like a flower than a round cell, the membrane is solidified and fibrous. In the first picture you can see a red blood cell damaged by alcohol (patient with liver cirrhosis), a so-called acanthocyte. The second picture shows an erythrocyte that has regained its original membrane functionality through additional administration of PPC.
Further studies on the effect of PPC in alcoholic fatty liver
One of the leading researchers on alcoholic fatty liver was Charles Lieber, a liver specialist from the USA. Frankly, you don’t necessarily have to agree with all the research he did on several species of animals, for example rats, but also baboons. What we mean by that is that he first made these animals dependent on alcohol and then treated them with PPC. You really don’t have to like that. Nevertheless, we want to present his results to you, because they can be transferred to alcohol-dependent humans without approving his methods.
In a group of alcohol-dependent rats, for example, he studied the activity of the protein cytochrome oxidase. Cytochrome oxidase controls oxygen uptake in the mitochondria, the power plants of our cells. This is greatly reduced by alcohol consumption. When PPC was administered, the activity of this enzyme was almost restored to normal. In another group of rats, he studied the effect of PPC on fibrosis of the liver (see Part 1). Using imaging techniques, he was able to demonstrate that the fibrosis of the cells could be significantly reduced.
Now let’s move on to the baboons. Lieber fed one group alcohol for 7-8 years, making them dependent. One group was also given PPC. The differences between the two groups were very impressive. While the group without PPC went through almost all stages from fatty liver to fibrosis to cirrhosis, the progression of the disease in the group that additionally received PPC was slowed down considerably and also did not reach the severity levels as in the other group. The picture shows the courses in both groups. We would like to add that 98% of the baboon’s genes match those of humans.
Points from top to down: cirrhosis, septal fibrosis, perivenular fibrosis, fat, normal
The studies were conducted over a 7-year period.
By the way, the results do not mean that we advise you to continue to drink large amounts of alcohol and then take PPC in addition, just because PPC changes the course of the disease. No, we just want to point out that for people who drink larger amounts of alcohol, in addition to reducing the amount of alcohol, PPC should also act as a supportive therapy.
Other studies, especially by Russian scientists, have shown further links between PPC intake and changes in alcoholism. These studies usually involve the fact that individual proteins were able to better cope with certain control functions again. One study even showed that the survival rate of patients with alcoholic hepatitis was significantly improved by PPC administration.
In summary, we can say that excessive alcohol consumption leads to fatty liver and then progressively to fibrosis and cirrhosis. Of course, these patients should be advised first and foremost to discover the reasons for their excessive alcohol consumption in order to thereby deal with their addiction problems. Nevertheless, it makes sense to also treat the physical damage of the supply of toxic alcohol.
What can you do in the event of alcohol-related damage?
In case of years of excessive and continuous alcohol consumption, intravenous therapy with PPC is advised. Intravenous means that PPC is given as an infusion in a glucose dilution (sugar solution). This must be done because the solubilizer that dissolves the PPC (actually a poorly soluble powdery substance) in liquid is a toxic substance, deoxycholic acid (DOC). By diluting it with the sugar solution, this toxicity can be diluted to such an extent that it is not harmful to the organism, because DOC loses toxicity very much when it is present in combination with PPC. If you take PPC with DOC undiluted, you still can’t get poisoned, but it can cause the veins where it is injected to get inflamed and that is not pleasant. So: when we think of toxin, we always think of poisoning, but as always, it depends on the dosage. In this formulation, PPC has been used for more than 40 years and except for a few vein irritations, nothing has happened.
A newly developed PPC variant is Nano PPC, which is produced by a German pharmacy as a prescription. Because it does not contain DOC, it should not be infused, but the Nano PPC should be slowly injected directly into the vein.
By the way, nano does not mean that technically produced foreign particles are used to introduce the PPC, but rather that the size of the PPC molecules has been reduced by complex technical processes so that they are nano-sized. 1 nanometer is the billionth part of a meter, i.e. extremely small.
The nano size of the PPC molecules causes them to be absorbed better and in greater quantities into the cell membranes. This is called bioavailability. The nano PPC is much higher than the normal PPC, and therefore the concentration of the PPC or the amount can be reduced by 50%.
Depending on the severity of the alcohol-related damage, at least 10 up to 30 infusions or injections must be given to stabilize the condition. If you want to undergo the treatment also called Vita-Balance Cure or Cell Rejuvenation Therapy (CRT), it is best to contact the experts of the Network Globalhealth and use the search engine to find the right doctor in your area. Click here to go to the network’s doctor search.
Now we come to the connoisseurs of alcohol, who themselves have not even noticed that there is a dependence. If you drink half a bottle to a bottle of wine or 2 bottles of beer every evening, you can already speak of a dependency.
In this case, you are strongly advised to break the continuity of drinking, e.g. to drink alcohol only every 2nd or 3rd day. In addition, we can recommend taking a PPC in capsule form to reverse the damage to the liver (how long have you already been drinking this amount?).
For this purpose, the Globalhealth network has developed Memphosan, a PPC that contains 450 milligrams per capsule. At least 2, better 4 capsules per day can improve liver activity and defat. Here we have connected you to the network’s store through an affiliate link.
Part 4 is about non-alcoholic fatty liver.
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Navder KP, Lieber CS: Dilinoleoylphosphatidylcholine is responsible for the beneficial effects of polyenylphosphatidylcholine on ethanol-induced mitochondrial injury in rats. Biochem Biophys Res Commun, 2002, 291, 1109–1112.
Ma X, Zhao J, Lieber CS: Polyenylphosphatidylcholine attenuates non-alcoholic hepatic fibrosis and accelerates its regression. J Hepatol, 1996, 24, 604–613.
Lieber CS, Robins SJ, Leo MA: Hepatic phosphatidylethanolamine methyltransferase activity is decreased by ethanol and increased by phosphatidylcholine. Alcohol Clin Exp Res, 1994, 18, 592–595.
Salvioli, G.: The effect of EPL administration in liver cirrhosis. Z. Gastroenterol. (Suppl. 2)
29(1991) 30-33
Sas E, Grinevich V, Kravchuk O, Efimov O: Polyunsaturated phosphatidylcholine reduces insulin resistance and hepatic fibrosis in patients with alcoholic liver disease. Results of randomized blinded prospective clinical study. J. Hepatol. 2011; 54: S 207
Bird JLA et al: Die Rolle der essentiellen Phospholipide in der Therapie von Lebererkrankungen: Analyse der aktuellen wissenschaftlichen Erkenntnisse. Z. Gastroenterol. (Suppl 2) 1991; 29: 21-4
Karl-Josef Gundermann , Ann Kuenker , Erwin Kuntz , Marek DroŸdzik: Activity of essential phospholipids (EPL) from soybean in liver diseases. Pharmacological reports: PR · May 2011, DOI: 10.1016/S1734-1140(11)70576-X